MOG-associated NMO Neuromyelitis optica

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currently, promising non-aquaporin biomarker presence of anti-mog autoantibody, anti-aqp4 can classify nmo cases in 4 classes, according presence or absence of of 2 antibodies.


mog antibodies considered absent in multiple sclerosis. therefore, can said anti-mog group contained inside aqp-negative nmo.


the clinical course , response therapy different these groups, showing better prognosis in nmo-ab(−)/mog-ab(−) group, , worse prognosis in nmo-ab(+)/mog-ab(+) group. mog-related neuromyelitis optica can radiologically identified conus involvement. myelin-oligodendrocyte glycoprotein antibody–positive patients more have conus involvement on spinal magnetic resonance imaging.








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