Neuropsychiatric Gut flora

interest in relationship between gut flora , neuropsychiatric issues sparked 2004 study showing germ-free mice showed exaggerated hpa axis response stress compared non-gf laboratory mice. of january 2016, of work has been done on role of gut flora in gut-brain axis had been conducted in animals, or characterizing various neuroactive compounds gut flora can produce, , studies humans measuring differences between people various psychiatric , neurological differences, or changes gut flora in response stress, or measuring effects of various probiotics (dubbed psychobiotics in context), had been small , not generalized; whether changes gut flora result of disease, cause of disease, or both in number of possible feedback loops in gut-brain axis, remained unclear.

a systematic review 2016 examined preclinical , small human trials have been conducted commercially available strains of probiotic bacteria , found among tested, bifidobacterium , lactobacillus genera (b. longum, b. breve, b. infantis, l. helveticus, l. rhamnosus, l. plantarum, , l. casei), had potential useful central nervous system disorders.